N G Properties of 7 S Rabbit and Sheep Antibodies
نویسنده
چکیده
The functional structure of gamma globulins and antibodies has recently come under intensive investigation through the use of reduction and alkylation of disulfide bonds (1). This method has revealed the great similarity in fundamental polypeptide chain structure among many species as well as between the different classes of immunoglobulins (2). By contrast, reduction of disulfide bonds affects immunological properties of different antibodies to varying degrees.
منابع مشابه
The Role of Disulfide Bonds in the Complement-fixing and Precipitating Properties of 7s Rabbit and Sheep Antibodies
The number of total disulfide bonds in rabbit and sheep 7S gamma globulin, before and after treatment with 2-mercaptoethanol, has been measured by amperometric titration. Mercaptan reduction could diminish the complement-fixing efficiency of 7S rabbit gamma globulin by no more than 90 per cent without any significant decrease in maximal complement-fixing ability. This was associated with the re...
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